英文标题

Exogenous nucleotide intervention can significantly
Reduce DNA methylation age by 3.08 years

Announcement of human trial results

On May 28, 2025, the internationally authoritative journal "Advanced Science", with an impact factor of 14.3, published the results of a large-scale human trial on exogenous nucleotides for anti-aging conducted by the research team led by Professor Li Yong from the Department of Nutrition and Food Hygiene at Peking University. The project studied the use of nucleotides obtained by enzymatically hydrolyzing eukaryotic cells from edible yeast, confirming that exogenous nucleotide intervention can significantly reduce the DNA methylation age of the tested population by 3.08 years. This provides a solid scientific basis for nucleotide anti-aging and contributes a new "Chinese approach" to the global anti-aging academic community. The study included 121 participants aged 60-70, employing an internationally recognized randomized double-blind controlled trial, and its rigor and authority have been highly praised by the academic community.

Integrate high-quality resources and continuously promote scientific research and innovation

Zhen'ao has currently established China's largest nucleic acid industrialization base and is one of the few enterprises in the world that have integrated the entire upstream and downstream nucleotide industry chain. The ribonucleic acid produced by the company is one of the few RNA products in the world that have passed GMA-SAFE (Global Manufacturing Accreditation Forum - Safe Assured Food Excellence) certification. The company has been invited to participate in the formulation of the world's first international standard for food-grade ribonucleic acid.

Breakthrough discovery in "Research on Nucleotides in Delaying Aging and Extending Healthy Lifespan"

02 
In 2022, the project titled "Research on Nucleotides in Delaying Aging and Extending Healthy Lifespan" achieved a significant breakthrough. The results of animal experiments on nucleotides have been appraised by an expert panel led by two academicians of the Chinese Academy of Engineering, Sun Baoguo and Han Demin.
03 
During the multi-generation rat reproduction safety experiment conducted by the research team at Peking University, they unexpectedly discovered that nucleotides have the effect of delaying aging, and officially initiated the project at the end of 2019.
04 
In 2000, Chen Yusong, the founder of Zhen'ao, commissioned a research team from Peking University to conduct research on the safety and functionality of nucleotides, which has been ongoing for nearly 20 years.

Project appraisal conclusion

The experimental results showed that the median survival time of SAMP8 mice with lifelong nucleotide intervention was extended by 9.21%-12.6%, equivalent to an extension of human lifespan by 8.76-12.0
Nucleotides have the effect of delaying aging and extending healthy lifespan, and the overall research achievements are at the international leading level.

Research and Innovation

Driven by scientific research and committed to serving the country through industry, Zhen'ao is dedicated to promoting high-quality development in the industry. With the highest quality products and services, it safeguards the health of the Chinese people.

10+
We have established long-term and stable cooperative relationships with universities such as Peking University and the School of Public Health at Fudan University, as well as institutions like the Institute of Materia Medica, Chinese Academy of Sciences, and the Institute of Immunology and Pathology at the University of Zurich
100%
Led by 9 Ph.D. holders and 46 master's degree holders
Professionals engaged in scientific research
28位 28位诺贝尔奖科学家先后到访
特聘5位诺奖科学家作为科研顾问
10billion
Accumulated R&D expenses invested in the past ten years
More than RMB 1 billion

Strong scientific research capability

Intellectual property patent technology

We have obtained nearly a hundred domestic and international intellectual property patents and technologies

technology project

Undertaking projects from the National "Eleventh Five-Year" Science and Technology Support Program, as well as science and technology plan projects in Liaoning Province and Dalian City

scientific research collaboration

We have established long-term and stable cooperative relationships with Peking University, Sichuan University, the School of Public Health at Fudan University, the School of Basic Medical Sciences at Tongji University, Dalian University of Technology, Liaoning University of Chinese Medicine, Gachon University College of Medicine in South Korea, and other universities.

Establish long-term and stable cooperative relationships with institutions such as the Institute of Materia Medica, Chinese Academy of Sciences, China National Research Institute of Food and Fermentation Industries, Texas Medical Research Institute, Institute of Immunology and Pathology, University of Zurich, and Japan Gene Nutrition Research Institute.

research team

A young and energetic research team led by 7 Ph.D. holders

Nobel Prize visit

28 Nobel Prize-winning scientists visited

Five Nobel Prize-winning scientists have been specially appointed as scientific research advisors